Abstract

Nanoprobes with multiple imaging modality have attracted a great deal of attention due to the capability of offering complementary information from each individual component. This work presents a hybrid approach to synthesize manganese doped near infrared (NIR) emitting quantum dots. The Mn-doping process was accomplished in aqueous phase followed by a phase transfer to organic phase for ZnS coating. This bimodal nanoprobe displayed high NIR luminescence quantum yield (~14%) and capability of magnetic resonance imaging (MRI) (1.44 mM−1 s−1). The RGD-targeted nanoprobes have been exploited for in vitro cell labelling, in vivo tumor targeting and lymph node mapping. In addition, no adverse toxic effects were observed, demonstrating the high biocompatibility of this nanoprobe.

© 2016 Optical Society of America

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References

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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref]

2016 (1)

T. Jin and Y. Imamura, “Applications of highly bright pbs quantum dots to non-invasive near-infrared fluorescence imaging in the second optical window,” ECS J. Solid State Sci. Technol. 5(1), R3138–R3145 (2016).
[Crossref]

2014 (3)

G. Sitbon, S. Bouccara, M. Tasso, A. Francois, L. Bezdetnaya, F. Marchal, M. Beaumont, and T. Pons, “Multimodal Mn-doped I-III-VI quantum dots for near infrared fluorescence and magnetic resonance imaging: from synthesis to in vivo application,” Nanoscale 6(15), 9264–9272 (2014).
[Crossref] [PubMed]

L. J. Sang and H. F. Wang, “Aminophenylboronic-acid-conjugated polyacrylic acid-Mn-doped ZnS quantum dot for highly sensitive discrimination of glycoproteins,” Anal. Chem. 86(12), 5706–5712 (2014).
[Crossref] [PubMed]

B. E. Rolfe, I. Blakey, O. Squires, H. Peng, N. R. B. Boase, C. Alexander, P. G. Parsons, G. M. Boyle, A. K. Whittaker, and K. J. Thurecht, “Multimodal polymer nanoparticles with combined 19f magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo,” J. Am. Chem. Soc. 136(6), 2413–2419 (2014).
[Crossref] [PubMed]

2013 (5)

Q. Xiao, X. Zheng, W. Bu, W. Ge, S. Zhang, F. Chen, H. Xing, Q. Ren, W. Fan, K. Zhao, Y. Hua, and J. Shi, “A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy,” J. Am. Chem. Soc. 135(35), 13041–13048 (2013).
[Crossref] [PubMed]

X. Liu, C. Lee, W.-C. Law, D. Zhu, M. Liu, M. Jeon, J. Kim, P. N. Prasad, C. Kim, and M. T. Swihart, “Au-Cu2-xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging,” Nano Lett. 13(9), 4333–4339 (2013).
[Crossref] [PubMed]

L. Damalakiene, V. Karabanovas, S. Bagdonas, M. Valius, and R. Rotomskis, “Intracellular distribution of nontargeted quantum dots after natural uptake and microinjection,” Int. J. Nanomedicine 8(10), 555–568 (2013).
[Crossref] [PubMed]

L. Turyanska, F. Moro, A. N. Knott, M. W. Fay, T. D. Bradshaw, and A. Patanè, “Paramagnetic, near-infrared fluorescent mn-doped pbs colloidal nanocrystals,” Part. Part. Syst. Charact. 30(11), 945–949 (2013).
[Crossref]

J. Liu, W.-C. Law, J. Liu, R. Hu, L. Liu, J. Zhu, H. Chen, J. Wang, Y. Hu, L. Ye, and K.-T. Yong, “Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice,” RSC Advances 3(6), 1768–1773 (2013).
[Crossref]

2012 (2)

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

G. Chen, T. Y. Ohulchanskyy, S. Liu, W. C. Law, F. Wu, M. T. Swihart, H. Agren, and P. N. Prasad, “Core/shell NaGdF4:Nd3+/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications,” ACS Nano 6(4), 2969–2977 (2012).
[Crossref] [PubMed]

2011 (3)

G. J. Stasiuk, S. Tamang, D. Imbert, C. Poillot, M. Giardiello, C. Tisseyre, E. L. Barbier, P. H. Fries, M. de Waard, P. Reiss, and M. Mazzanti, “Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents,” ACS Nano 5(10), 8193–8201 (2011).
[Crossref] [PubMed]

L. Liu, W. C. Law, K. T. Yong, I. Roy, H. Ding, F. Erogbogbo, X. Zhang, and P. N. Prasad, “Multimodal imaging probes based on Gd-DOTA conjugated quantum dot nanomicelles,” Analyst (Lond.) 136(9), 1881–1886 (2011).
[Crossref] [PubMed]

S. K. Panda, S. G. Hickey, H. V. Demir, and A. Eychmüller, “Bright white-light emitting manganese and copper co-doped ZnSe quantum dots,” Angew. Chem. Int. Ed. Engl. 50(19), 4432–4436 (2011).
[Crossref] [PubMed]

2010 (1)

2009 (2)

W.-C. Law, K.-T. Yong, I. Roy, H. Ding, R. Hu, W. Zhao, and P. N. Prasad, “Aqueous-phase synthesis of highly luminescent cdte/znte core/shell quantum dots optimized for targeted bioimaging,” Small 5(11), 1302–1310 (2009).
[Crossref] [PubMed]

K.-T. Yong, “Mn-doped near-infrared quantum dots as multimodal targeted probes for pancreatic cancer imaging,” Nanotechnology 20(1), 015102 (2009).
[Crossref] [PubMed]

2004 (1)

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

2001 (1)

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grötzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19(4), 327–331 (2001).
[Crossref] [PubMed]

Agren, H.

G. Chen, T. Y. Ohulchanskyy, S. Liu, W. C. Law, F. Wu, M. T. Swihart, H. Agren, and P. N. Prasad, “Core/shell NaGdF4:Nd3+/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications,” ACS Nano 6(4), 2969–2977 (2012).
[Crossref] [PubMed]

Alexander, C.

B. E. Rolfe, I. Blakey, O. Squires, H. Peng, N. R. B. Boase, C. Alexander, P. G. Parsons, G. M. Boyle, A. K. Whittaker, and K. J. Thurecht, “Multimodal polymer nanoparticles with combined 19f magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo,” J. Am. Chem. Soc. 136(6), 2413–2419 (2014).
[Crossref] [PubMed]

Bagdonas, S.

L. Damalakiene, V. Karabanovas, S. Bagdonas, M. Valius, and R. Rotomskis, “Intracellular distribution of nontargeted quantum dots after natural uptake and microinjection,” Int. J. Nanomedicine 8(10), 555–568 (2013).
[Crossref] [PubMed]

Barbier, E. L.

G. J. Stasiuk, S. Tamang, D. Imbert, C. Poillot, M. Giardiello, C. Tisseyre, E. L. Barbier, P. H. Fries, M. de Waard, P. Reiss, and M. Mazzanti, “Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents,” ACS Nano 5(10), 8193–8201 (2011).
[Crossref] [PubMed]

Bawendi, M. G.

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

Beaumont, M.

G. Sitbon, S. Bouccara, M. Tasso, A. Francois, L. Bezdetnaya, F. Marchal, M. Beaumont, and T. Pons, “Multimodal Mn-doped I-III-VI quantum dots for near infrared fluorescence and magnetic resonance imaging: from synthesis to in vivo application,” Nanoscale 6(15), 9264–9272 (2014).
[Crossref] [PubMed]

Becker, A.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grötzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19(4), 327–331 (2001).
[Crossref] [PubMed]

Bezdetnaya, L.

G. Sitbon, S. Bouccara, M. Tasso, A. Francois, L. Bezdetnaya, F. Marchal, M. Beaumont, and T. Pons, “Multimodal Mn-doped I-III-VI quantum dots for near infrared fluorescence and magnetic resonance imaging: from synthesis to in vivo application,” Nanoscale 6(15), 9264–9272 (2014).
[Crossref] [PubMed]

Blakey, I.

B. E. Rolfe, I. Blakey, O. Squires, H. Peng, N. R. B. Boase, C. Alexander, P. G. Parsons, G. M. Boyle, A. K. Whittaker, and K. J. Thurecht, “Multimodal polymer nanoparticles with combined 19f magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo,” J. Am. Chem. Soc. 136(6), 2413–2419 (2014).
[Crossref] [PubMed]

Boase, N. R. B.

B. E. Rolfe, I. Blakey, O. Squires, H. Peng, N. R. B. Boase, C. Alexander, P. G. Parsons, G. M. Boyle, A. K. Whittaker, and K. J. Thurecht, “Multimodal polymer nanoparticles with combined 19f magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo,” J. Am. Chem. Soc. 136(6), 2413–2419 (2014).
[Crossref] [PubMed]

Bouccara, S.

G. Sitbon, S. Bouccara, M. Tasso, A. Francois, L. Bezdetnaya, F. Marchal, M. Beaumont, and T. Pons, “Multimodal Mn-doped I-III-VI quantum dots for near infrared fluorescence and magnetic resonance imaging: from synthesis to in vivo application,” Nanoscale 6(15), 9264–9272 (2014).
[Crossref] [PubMed]

Boyle, G. M.

B. E. Rolfe, I. Blakey, O. Squires, H. Peng, N. R. B. Boase, C. Alexander, P. G. Parsons, G. M. Boyle, A. K. Whittaker, and K. J. Thurecht, “Multimodal polymer nanoparticles with combined 19f magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo,” J. Am. Chem. Soc. 136(6), 2413–2419 (2014).
[Crossref] [PubMed]

Bradshaw, T. D.

L. Turyanska, F. Moro, A. N. Knott, M. W. Fay, T. D. Bradshaw, and A. Patanè, “Paramagnetic, near-infrared fluorescent mn-doped pbs colloidal nanocrystals,” Part. Part. Syst. Charact. 30(11), 945–949 (2013).
[Crossref]

Bu, W.

Q. Xiao, X. Zheng, W. Bu, W. Ge, S. Zhang, F. Chen, H. Xing, Q. Ren, W. Fan, K. Zhao, Y. Hua, and J. Shi, “A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy,” J. Am. Chem. Soc. 135(35), 13041–13048 (2013).
[Crossref] [PubMed]

Cai, H.

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

Capobianco, J. A.

Chen, F.

Q. Xiao, X. Zheng, W. Bu, W. Ge, S. Zhang, F. Chen, H. Xing, Q. Ren, W. Fan, K. Zhao, Y. Hua, and J. Shi, “A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy,” J. Am. Chem. Soc. 135(35), 13041–13048 (2013).
[Crossref] [PubMed]

Chen, G.

G. Chen, T. Y. Ohulchanskyy, S. Liu, W. C. Law, F. Wu, M. T. Swihart, H. Agren, and P. N. Prasad, “Core/shell NaGdF4:Nd3+/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications,” ACS Nano 6(4), 2969–2977 (2012).
[Crossref] [PubMed]

Chen, H.

J. Liu, W.-C. Law, J. Liu, R. Hu, L. Liu, J. Zhu, H. Chen, J. Wang, Y. Hu, L. Ye, and K.-T. Yong, “Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice,” RSC Advances 3(6), 1768–1773 (2013).
[Crossref]

Cohn, L. H.

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

Damalakiene, L.

L. Damalakiene, V. Karabanovas, S. Bagdonas, M. Valius, and R. Rotomskis, “Intracellular distribution of nontargeted quantum dots after natural uptake and microinjection,” Int. J. Nanomedicine 8(10), 555–568 (2013).
[Crossref] [PubMed]

De Grand, A. M.

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

de Waard, M.

G. J. Stasiuk, S. Tamang, D. Imbert, C. Poillot, M. Giardiello, C. Tisseyre, E. L. Barbier, P. H. Fries, M. de Waard, P. Reiss, and M. Mazzanti, “Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents,” ACS Nano 5(10), 8193–8201 (2011).
[Crossref] [PubMed]

Demir, H. V.

S. K. Panda, S. G. Hickey, H. V. Demir, and A. Eychmüller, “Bright white-light emitting manganese and copper co-doped ZnSe quantum dots,” Angew. Chem. Int. Ed. Engl. 50(19), 4432–4436 (2011).
[Crossref] [PubMed]

Ding, H.

L. Liu, W. C. Law, K. T. Yong, I. Roy, H. Ding, F. Erogbogbo, X. Zhang, and P. N. Prasad, “Multimodal imaging probes based on Gd-DOTA conjugated quantum dot nanomicelles,” Analyst (Lond.) 136(9), 1881–1886 (2011).
[Crossref] [PubMed]

W.-C. Law, K.-T. Yong, I. Roy, H. Ding, R. Hu, W. Zhao, and P. N. Prasad, “Aqueous-phase synthesis of highly luminescent cdte/znte core/shell quantum dots optimized for targeted bioimaging,” Small 5(11), 1302–1310 (2009).
[Crossref] [PubMed]

Dor, D. M.

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

Ebert, B.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grötzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19(4), 327–331 (2001).
[Crossref] [PubMed]

Erogbogbo, F.

L. Liu, W. C. Law, K. T. Yong, I. Roy, H. Ding, F. Erogbogbo, X. Zhang, and P. N. Prasad, “Multimodal imaging probes based on Gd-DOTA conjugated quantum dot nanomicelles,” Analyst (Lond.) 136(9), 1881–1886 (2011).
[Crossref] [PubMed]

Eychmüller, A.

S. K. Panda, S. G. Hickey, H. V. Demir, and A. Eychmüller, “Bright white-light emitting manganese and copper co-doped ZnSe quantum dots,” Angew. Chem. Int. Ed. Engl. 50(19), 4432–4436 (2011).
[Crossref] [PubMed]

Fan, W.

Q. Xiao, X. Zheng, W. Bu, W. Ge, S. Zhang, F. Chen, H. Xing, Q. Ren, W. Fan, K. Zhao, Y. Hua, and J. Shi, “A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy,” J. Am. Chem. Soc. 135(35), 13041–13048 (2013).
[Crossref] [PubMed]

Fay, M. W.

L. Turyanska, F. Moro, A. N. Knott, M. W. Fay, T. D. Bradshaw, and A. Patanè, “Paramagnetic, near-infrared fluorescent mn-doped pbs colloidal nanocrystals,” Part. Part. Syst. Charact. 30(11), 945–949 (2013).
[Crossref]

Francois, A.

G. Sitbon, S. Bouccara, M. Tasso, A. Francois, L. Bezdetnaya, F. Marchal, M. Beaumont, and T. Pons, “Multimodal Mn-doped I-III-VI quantum dots for near infrared fluorescence and magnetic resonance imaging: from synthesis to in vivo application,” Nanoscale 6(15), 9264–9272 (2014).
[Crossref] [PubMed]

Frangioni, J. V.

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

Fries, P. H.

G. J. Stasiuk, S. Tamang, D. Imbert, C. Poillot, M. Giardiello, C. Tisseyre, E. L. Barbier, P. H. Fries, M. de Waard, P. Reiss, and M. Mazzanti, “Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents,” ACS Nano 5(10), 8193–8201 (2011).
[Crossref] [PubMed]

Ge, W.

Q. Xiao, X. Zheng, W. Bu, W. Ge, S. Zhang, F. Chen, H. Xing, Q. Ren, W. Fan, K. Zhao, Y. Hua, and J. Shi, “A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy,” J. Am. Chem. Soc. 135(35), 13041–13048 (2013).
[Crossref] [PubMed]

Giardiello, M.

G. J. Stasiuk, S. Tamang, D. Imbert, C. Poillot, M. Giardiello, C. Tisseyre, E. L. Barbier, P. H. Fries, M. de Waard, P. Reiss, and M. Mazzanti, “Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents,” ACS Nano 5(10), 8193–8201 (2011).
[Crossref] [PubMed]

Grötzinger, C.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grötzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19(4), 327–331 (2001).
[Crossref] [PubMed]

Hessenius, C.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grötzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19(4), 327–331 (2001).
[Crossref] [PubMed]

Hickey, S. G.

S. K. Panda, S. G. Hickey, H. V. Demir, and A. Eychmüller, “Bright white-light emitting manganese and copper co-doped ZnSe quantum dots,” Angew. Chem. Int. Ed. Engl. 50(19), 4432–4436 (2011).
[Crossref] [PubMed]

Hu, R.

J. Liu, W.-C. Law, J. Liu, R. Hu, L. Liu, J. Zhu, H. Chen, J. Wang, Y. Hu, L. Ye, and K.-T. Yong, “Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice,” RSC Advances 3(6), 1768–1773 (2013).
[Crossref]

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

W.-C. Law, K.-T. Yong, I. Roy, H. Ding, R. Hu, W. Zhao, and P. N. Prasad, “Aqueous-phase synthesis of highly luminescent cdte/znte core/shell quantum dots optimized for targeted bioimaging,” Small 5(11), 1302–1310 (2009).
[Crossref] [PubMed]

Hu, Y.

J. Liu, W.-C. Law, J. Liu, R. Hu, L. Liu, J. Zhu, H. Chen, J. Wang, Y. Hu, L. Ye, and K.-T. Yong, “Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice,” RSC Advances 3(6), 1768–1773 (2013).
[Crossref]

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

Hua, Y.

Q. Xiao, X. Zheng, W. Bu, W. Ge, S. Zhang, F. Chen, H. Xing, Q. Ren, W. Fan, K. Zhao, Y. Hua, and J. Shi, “A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy,” J. Am. Chem. Soc. 135(35), 13041–13048 (2013).
[Crossref] [PubMed]

Imamura, Y.

T. Jin and Y. Imamura, “Applications of highly bright pbs quantum dots to non-invasive near-infrared fluorescence imaging in the second optical window,” ECS J. Solid State Sci. Technol. 5(1), R3138–R3145 (2016).
[Crossref]

Imbert, D.

G. J. Stasiuk, S. Tamang, D. Imbert, C. Poillot, M. Giardiello, C. Tisseyre, E. L. Barbier, P. H. Fries, M. de Waard, P. Reiss, and M. Mazzanti, “Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents,” ACS Nano 5(10), 8193–8201 (2011).
[Crossref] [PubMed]

Jaque, D.

Jeon, M.

X. Liu, C. Lee, W.-C. Law, D. Zhu, M. Liu, M. Jeon, J. Kim, P. N. Prasad, C. Kim, and M. T. Swihart, “Au-Cu2-xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging,” Nano Lett. 13(9), 4333–4339 (2013).
[Crossref] [PubMed]

Jin, T.

T. Jin and Y. Imamura, “Applications of highly bright pbs quantum dots to non-invasive near-infrared fluorescence imaging in the second optical window,” ECS J. Solid State Sci. Technol. 5(1), R3138–R3145 (2016).
[Crossref]

Karabanovas, V.

L. Damalakiene, V. Karabanovas, S. Bagdonas, M. Valius, and R. Rotomskis, “Intracellular distribution of nontargeted quantum dots after natural uptake and microinjection,” Int. J. Nanomedicine 8(10), 555–568 (2013).
[Crossref] [PubMed]

Kim, C.

X. Liu, C. Lee, W.-C. Law, D. Zhu, M. Liu, M. Jeon, J. Kim, P. N. Prasad, C. Kim, and M. T. Swihart, “Au-Cu2-xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging,” Nano Lett. 13(9), 4333–4339 (2013).
[Crossref] [PubMed]

Kim, J.

X. Liu, C. Lee, W.-C. Law, D. Zhu, M. Liu, M. Jeon, J. Kim, P. N. Prasad, C. Kim, and M. T. Swihart, “Au-Cu2-xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging,” Nano Lett. 13(9), 4333–4339 (2013).
[Crossref] [PubMed]

Kim, S.

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

Knott, A. N.

L. Turyanska, F. Moro, A. N. Knott, M. W. Fay, T. D. Bradshaw, and A. Patanè, “Paramagnetic, near-infrared fluorescent mn-doped pbs colloidal nanocrystals,” Part. Part. Syst. Charact. 30(11), 945–949 (2013).
[Crossref]

Laurence, R. G.

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

Law, W. C.

G. Chen, T. Y. Ohulchanskyy, S. Liu, W. C. Law, F. Wu, M. T. Swihart, H. Agren, and P. N. Prasad, “Core/shell NaGdF4:Nd3+/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications,” ACS Nano 6(4), 2969–2977 (2012).
[Crossref] [PubMed]

L. Liu, W. C. Law, K. T. Yong, I. Roy, H. Ding, F. Erogbogbo, X. Zhang, and P. N. Prasad, “Multimodal imaging probes based on Gd-DOTA conjugated quantum dot nanomicelles,” Analyst (Lond.) 136(9), 1881–1886 (2011).
[Crossref] [PubMed]

Law, W.-C.

X. Liu, C. Lee, W.-C. Law, D. Zhu, M. Liu, M. Jeon, J. Kim, P. N. Prasad, C. Kim, and M. T. Swihart, “Au-Cu2-xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging,” Nano Lett. 13(9), 4333–4339 (2013).
[Crossref] [PubMed]

J. Liu, W.-C. Law, J. Liu, R. Hu, L. Liu, J. Zhu, H. Chen, J. Wang, Y. Hu, L. Ye, and K.-T. Yong, “Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice,” RSC Advances 3(6), 1768–1773 (2013).
[Crossref]

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

W.-C. Law, K.-T. Yong, I. Roy, H. Ding, R. Hu, W. Zhao, and P. N. Prasad, “Aqueous-phase synthesis of highly luminescent cdte/znte core/shell quantum dots optimized for targeted bioimaging,” Small 5(11), 1302–1310 (2009).
[Crossref] [PubMed]

Lee, C.

X. Liu, C. Lee, W.-C. Law, D. Zhu, M. Liu, M. Jeon, J. Kim, P. N. Prasad, C. Kim, and M. T. Swihart, “Au-Cu2-xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging,” Nano Lett. 13(9), 4333–4339 (2013).
[Crossref] [PubMed]

Lee, J.

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

Licha, K.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grötzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19(4), 327–331 (2001).
[Crossref] [PubMed]

Lim, Y. T.

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

Liu, J.

J. Liu, W.-C. Law, J. Liu, R. Hu, L. Liu, J. Zhu, H. Chen, J. Wang, Y. Hu, L. Ye, and K.-T. Yong, “Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice,” RSC Advances 3(6), 1768–1773 (2013).
[Crossref]

J. Liu, W.-C. Law, J. Liu, R. Hu, L. Liu, J. Zhu, H. Chen, J. Wang, Y. Hu, L. Ye, and K.-T. Yong, “Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice,” RSC Advances 3(6), 1768–1773 (2013).
[Crossref]

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

Liu, L.

J. Liu, W.-C. Law, J. Liu, R. Hu, L. Liu, J. Zhu, H. Chen, J. Wang, Y. Hu, L. Ye, and K.-T. Yong, “Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice,” RSC Advances 3(6), 1768–1773 (2013).
[Crossref]

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

L. Liu, W. C. Law, K. T. Yong, I. Roy, H. Ding, F. Erogbogbo, X. Zhang, and P. N. Prasad, “Multimodal imaging probes based on Gd-DOTA conjugated quantum dot nanomicelles,” Analyst (Lond.) 136(9), 1881–1886 (2011).
[Crossref] [PubMed]

Liu, M.

X. Liu, C. Lee, W.-C. Law, D. Zhu, M. Liu, M. Jeon, J. Kim, P. N. Prasad, C. Kim, and M. T. Swihart, “Au-Cu2-xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging,” Nano Lett. 13(9), 4333–4339 (2013).
[Crossref] [PubMed]

Liu, S.

G. Chen, T. Y. Ohulchanskyy, S. Liu, W. C. Law, F. Wu, M. T. Swihart, H. Agren, and P. N. Prasad, “Core/shell NaGdF4:Nd3+/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications,” ACS Nano 6(4), 2969–2977 (2012).
[Crossref] [PubMed]

Liu, X.

X. Liu, C. Lee, W.-C. Law, D. Zhu, M. Liu, M. Jeon, J. Kim, P. N. Prasad, C. Kim, and M. T. Swihart, “Au-Cu2-xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging,” Nano Lett. 13(9), 4333–4339 (2013).
[Crossref] [PubMed]

Liu, Y.

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

Maestro, L. M.

Marchal, F.

G. Sitbon, S. Bouccara, M. Tasso, A. Francois, L. Bezdetnaya, F. Marchal, M. Beaumont, and T. Pons, “Multimodal Mn-doped I-III-VI quantum dots for near infrared fluorescence and magnetic resonance imaging: from synthesis to in vivo application,” Nanoscale 6(15), 9264–9272 (2014).
[Crossref] [PubMed]

Mazzanti, M.

G. J. Stasiuk, S. Tamang, D. Imbert, C. Poillot, M. Giardiello, C. Tisseyre, E. L. Barbier, P. H. Fries, M. de Waard, P. Reiss, and M. Mazzanti, “Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents,” ACS Nano 5(10), 8193–8201 (2011).
[Crossref] [PubMed]

Mihaljevic, T.

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

Moro, F.

L. Turyanska, F. Moro, A. N. Knott, M. W. Fay, T. D. Bradshaw, and A. Patanè, “Paramagnetic, near-infrared fluorescent mn-doped pbs colloidal nanocrystals,” Part. Part. Syst. Charact. 30(11), 945–949 (2013).
[Crossref]

Naccache, R.

Nakayama, A.

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

Ohulchanskyy, T. Y.

G. Chen, T. Y. Ohulchanskyy, S. Liu, W. C. Law, F. Wu, M. T. Swihart, H. Agren, and P. N. Prasad, “Core/shell NaGdF4:Nd3+/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications,” ACS Nano 6(4), 2969–2977 (2012).
[Crossref] [PubMed]

Panda, S. K.

S. K. Panda, S. G. Hickey, H. V. Demir, and A. Eychmüller, “Bright white-light emitting manganese and copper co-doped ZnSe quantum dots,” Angew. Chem. Int. Ed. Engl. 50(19), 4432–4436 (2011).
[Crossref] [PubMed]

Parker, J. A.

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

Parsons, P. G.

B. E. Rolfe, I. Blakey, O. Squires, H. Peng, N. R. B. Boase, C. Alexander, P. G. Parsons, G. M. Boyle, A. K. Whittaker, and K. J. Thurecht, “Multimodal polymer nanoparticles with combined 19f magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo,” J. Am. Chem. Soc. 136(6), 2413–2419 (2014).
[Crossref] [PubMed]

Patanè, A.

L. Turyanska, F. Moro, A. N. Knott, M. W. Fay, T. D. Bradshaw, and A. Patanè, “Paramagnetic, near-infrared fluorescent mn-doped pbs colloidal nanocrystals,” Part. Part. Syst. Charact. 30(11), 945–949 (2013).
[Crossref]

Peng, H.

B. E. Rolfe, I. Blakey, O. Squires, H. Peng, N. R. B. Boase, C. Alexander, P. G. Parsons, G. M. Boyle, A. K. Whittaker, and K. J. Thurecht, “Multimodal polymer nanoparticles with combined 19f magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo,” J. Am. Chem. Soc. 136(6), 2413–2419 (2014).
[Crossref] [PubMed]

Poillot, C.

G. J. Stasiuk, S. Tamang, D. Imbert, C. Poillot, M. Giardiello, C. Tisseyre, E. L. Barbier, P. H. Fries, M. de Waard, P. Reiss, and M. Mazzanti, “Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents,” ACS Nano 5(10), 8193–8201 (2011).
[Crossref] [PubMed]

Pons, T.

G. Sitbon, S. Bouccara, M. Tasso, A. Francois, L. Bezdetnaya, F. Marchal, M. Beaumont, and T. Pons, “Multimodal Mn-doped I-III-VI quantum dots for near infrared fluorescence and magnetic resonance imaging: from synthesis to in vivo application,” Nanoscale 6(15), 9264–9272 (2014).
[Crossref] [PubMed]

Prasad, P. N.

X. Liu, C. Lee, W.-C. Law, D. Zhu, M. Liu, M. Jeon, J. Kim, P. N. Prasad, C. Kim, and M. T. Swihart, “Au-Cu2-xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging,” Nano Lett. 13(9), 4333–4339 (2013).
[Crossref] [PubMed]

G. Chen, T. Y. Ohulchanskyy, S. Liu, W. C. Law, F. Wu, M. T. Swihart, H. Agren, and P. N. Prasad, “Core/shell NaGdF4:Nd3+/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications,” ACS Nano 6(4), 2969–2977 (2012).
[Crossref] [PubMed]

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

L. Liu, W. C. Law, K. T. Yong, I. Roy, H. Ding, F. Erogbogbo, X. Zhang, and P. N. Prasad, “Multimodal imaging probes based on Gd-DOTA conjugated quantum dot nanomicelles,” Analyst (Lond.) 136(9), 1881–1886 (2011).
[Crossref] [PubMed]

W.-C. Law, K.-T. Yong, I. Roy, H. Ding, R. Hu, W. Zhao, and P. N. Prasad, “Aqueous-phase synthesis of highly luminescent cdte/znte core/shell quantum dots optimized for targeted bioimaging,” Small 5(11), 1302–1310 (2009).
[Crossref] [PubMed]

Ramirez, H. L.

Reiss, P.

G. J. Stasiuk, S. Tamang, D. Imbert, C. Poillot, M. Giardiello, C. Tisseyre, E. L. Barbier, P. H. Fries, M. de Waard, P. Reiss, and M. Mazzanti, “Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents,” ACS Nano 5(10), 8193–8201 (2011).
[Crossref] [PubMed]

Ren, Q.

Q. Xiao, X. Zheng, W. Bu, W. Ge, S. Zhang, F. Chen, H. Xing, Q. Ren, W. Fan, K. Zhao, Y. Hua, and J. Shi, “A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy,” J. Am. Chem. Soc. 135(35), 13041–13048 (2013).
[Crossref] [PubMed]

Rodriguez, E. M.

Rolfe, B. E.

B. E. Rolfe, I. Blakey, O. Squires, H. Peng, N. R. B. Boase, C. Alexander, P. G. Parsons, G. M. Boyle, A. K. Whittaker, and K. J. Thurecht, “Multimodal polymer nanoparticles with combined 19f magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo,” J. Am. Chem. Soc. 136(6), 2413–2419 (2014).
[Crossref] [PubMed]

Rotomskis, R.

L. Damalakiene, V. Karabanovas, S. Bagdonas, M. Valius, and R. Rotomskis, “Intracellular distribution of nontargeted quantum dots after natural uptake and microinjection,” Int. J. Nanomedicine 8(10), 555–568 (2013).
[Crossref] [PubMed]

Roy, I.

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

L. Liu, W. C. Law, K. T. Yong, I. Roy, H. Ding, F. Erogbogbo, X. Zhang, and P. N. Prasad, “Multimodal imaging probes based on Gd-DOTA conjugated quantum dot nanomicelles,” Analyst (Lond.) 136(9), 1881–1886 (2011).
[Crossref] [PubMed]

W.-C. Law, K.-T. Yong, I. Roy, H. Ding, R. Hu, W. Zhao, and P. N. Prasad, “Aqueous-phase synthesis of highly luminescent cdte/znte core/shell quantum dots optimized for targeted bioimaging,” Small 5(11), 1302–1310 (2009).
[Crossref] [PubMed]

Sang, L. J.

L. J. Sang and H. F. Wang, “Aminophenylboronic-acid-conjugated polyacrylic acid-Mn-doped ZnS quantum dot for highly sensitive discrimination of glycoproteins,” Anal. Chem. 86(12), 5706–5712 (2014).
[Crossref] [PubMed]

Semmler, W.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grötzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19(4), 327–331 (2001).
[Crossref] [PubMed]

Shi, J.

Q. Xiao, X. Zheng, W. Bu, W. Ge, S. Zhang, F. Chen, H. Xing, Q. Ren, W. Fan, K. Zhao, Y. Hua, and J. Shi, “A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy,” J. Am. Chem. Soc. 135(35), 13041–13048 (2013).
[Crossref] [PubMed]

Sitbon, G.

G. Sitbon, S. Bouccara, M. Tasso, A. Francois, L. Bezdetnaya, F. Marchal, M. Beaumont, and T. Pons, “Multimodal Mn-doped I-III-VI quantum dots for near infrared fluorescence and magnetic resonance imaging: from synthesis to in vivo application,” Nanoscale 6(15), 9264–9272 (2014).
[Crossref] [PubMed]

Solé, J. G.

Soltesz, E. G.

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

Squires, O.

B. E. Rolfe, I. Blakey, O. Squires, H. Peng, N. R. B. Boase, C. Alexander, P. G. Parsons, G. M. Boyle, A. K. Whittaker, and K. J. Thurecht, “Multimodal polymer nanoparticles with combined 19f magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo,” J. Am. Chem. Soc. 136(6), 2413–2419 (2014).
[Crossref] [PubMed]

Stasiuk, G. J.

G. J. Stasiuk, S. Tamang, D. Imbert, C. Poillot, M. Giardiello, C. Tisseyre, E. L. Barbier, P. H. Fries, M. de Waard, P. Reiss, and M. Mazzanti, “Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents,” ACS Nano 5(10), 8193–8201 (2011).
[Crossref] [PubMed]

Sukowski, U.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grötzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19(4), 327–331 (2001).
[Crossref] [PubMed]

Swihart, M. T.

X. Liu, C. Lee, W.-C. Law, D. Zhu, M. Liu, M. Jeon, J. Kim, P. N. Prasad, C. Kim, and M. T. Swihart, “Au-Cu2-xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging,” Nano Lett. 13(9), 4333–4339 (2013).
[Crossref] [PubMed]

G. Chen, T. Y. Ohulchanskyy, S. Liu, W. C. Law, F. Wu, M. T. Swihart, H. Agren, and P. N. Prasad, “Core/shell NaGdF4:Nd3+/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications,” ACS Nano 6(4), 2969–2977 (2012).
[Crossref] [PubMed]

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

Tamang, S.

G. J. Stasiuk, S. Tamang, D. Imbert, C. Poillot, M. Giardiello, C. Tisseyre, E. L. Barbier, P. H. Fries, M. de Waard, P. Reiss, and M. Mazzanti, “Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents,” ACS Nano 5(10), 8193–8201 (2011).
[Crossref] [PubMed]

Tasso, M.

G. Sitbon, S. Bouccara, M. Tasso, A. Francois, L. Bezdetnaya, F. Marchal, M. Beaumont, and T. Pons, “Multimodal Mn-doped I-III-VI quantum dots for near infrared fluorescence and magnetic resonance imaging: from synthesis to in vivo application,” Nanoscale 6(15), 9264–9272 (2014).
[Crossref] [PubMed]

Thurecht, K. J.

B. E. Rolfe, I. Blakey, O. Squires, H. Peng, N. R. B. Boase, C. Alexander, P. G. Parsons, G. M. Boyle, A. K. Whittaker, and K. J. Thurecht, “Multimodal polymer nanoparticles with combined 19f magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo,” J. Am. Chem. Soc. 136(6), 2413–2419 (2014).
[Crossref] [PubMed]

Tisseyre, C.

G. J. Stasiuk, S. Tamang, D. Imbert, C. Poillot, M. Giardiello, C. Tisseyre, E. L. Barbier, P. H. Fries, M. de Waard, P. Reiss, and M. Mazzanti, “Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents,” ACS Nano 5(10), 8193–8201 (2011).
[Crossref] [PubMed]

Turyanska, L.

L. Turyanska, F. Moro, A. N. Knott, M. W. Fay, T. D. Bradshaw, and A. Patanè, “Paramagnetic, near-infrared fluorescent mn-doped pbs colloidal nanocrystals,” Part. Part. Syst. Charact. 30(11), 945–949 (2013).
[Crossref]

Valius, M.

L. Damalakiene, V. Karabanovas, S. Bagdonas, M. Valius, and R. Rotomskis, “Intracellular distribution of nontargeted quantum dots after natural uptake and microinjection,” Int. J. Nanomedicine 8(10), 555–568 (2013).
[Crossref] [PubMed]

Vetrone, F.

Wang, H. F.

L. J. Sang and H. F. Wang, “Aminophenylboronic-acid-conjugated polyacrylic acid-Mn-doped ZnS quantum dot for highly sensitive discrimination of glycoproteins,” Anal. Chem. 86(12), 5706–5712 (2014).
[Crossref] [PubMed]

Wang, J.

J. Liu, W.-C. Law, J. Liu, R. Hu, L. Liu, J. Zhu, H. Chen, J. Wang, Y. Hu, L. Ye, and K.-T. Yong, “Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice,” RSC Advances 3(6), 1768–1773 (2013).
[Crossref]

Wang, K.

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

Whittaker, A. K.

B. E. Rolfe, I. Blakey, O. Squires, H. Peng, N. R. B. Boase, C. Alexander, P. G. Parsons, G. M. Boyle, A. K. Whittaker, and K. J. Thurecht, “Multimodal polymer nanoparticles with combined 19f magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo,” J. Am. Chem. Soc. 136(6), 2413–2419 (2014).
[Crossref] [PubMed]

Wiedenmann, B.

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grötzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19(4), 327–331 (2001).
[Crossref] [PubMed]

Wu, F.

G. Chen, T. Y. Ohulchanskyy, S. Liu, W. C. Law, F. Wu, M. T. Swihart, H. Agren, and P. N. Prasad, “Core/shell NaGdF4:Nd3+/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications,” ACS Nano 6(4), 2969–2977 (2012).
[Crossref] [PubMed]

Xiao, Q.

Q. Xiao, X. Zheng, W. Bu, W. Ge, S. Zhang, F. Chen, H. Xing, Q. Ren, W. Fan, K. Zhao, Y. Hua, and J. Shi, “A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy,” J. Am. Chem. Soc. 135(35), 13041–13048 (2013).
[Crossref] [PubMed]

Xing, H.

Q. Xiao, X. Zheng, W. Bu, W. Ge, S. Zhang, F. Chen, H. Xing, Q. Ren, W. Fan, K. Zhao, Y. Hua, and J. Shi, “A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy,” J. Am. Chem. Soc. 135(35), 13041–13048 (2013).
[Crossref] [PubMed]

Ye, L.

J. Liu, W.-C. Law, J. Liu, R. Hu, L. Liu, J. Zhu, H. Chen, J. Wang, Y. Hu, L. Ye, and K.-T. Yong, “Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice,” RSC Advances 3(6), 1768–1773 (2013).
[Crossref]

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

Yong, K. T.

L. Liu, W. C. Law, K. T. Yong, I. Roy, H. Ding, F. Erogbogbo, X. Zhang, and P. N. Prasad, “Multimodal imaging probes based on Gd-DOTA conjugated quantum dot nanomicelles,” Analyst (Lond.) 136(9), 1881–1886 (2011).
[Crossref] [PubMed]

Yong, K.-T.

J. Liu, W.-C. Law, J. Liu, R. Hu, L. Liu, J. Zhu, H. Chen, J. Wang, Y. Hu, L. Ye, and K.-T. Yong, “Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice,” RSC Advances 3(6), 1768–1773 (2013).
[Crossref]

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

W.-C. Law, K.-T. Yong, I. Roy, H. Ding, R. Hu, W. Zhao, and P. N. Prasad, “Aqueous-phase synthesis of highly luminescent cdte/znte core/shell quantum dots optimized for targeted bioimaging,” Small 5(11), 1302–1310 (2009).
[Crossref] [PubMed]

K.-T. Yong, “Mn-doped near-infrared quantum dots as multimodal targeted probes for pancreatic cancer imaging,” Nanotechnology 20(1), 015102 (2009).
[Crossref] [PubMed]

Zhang, S.

Q. Xiao, X. Zheng, W. Bu, W. Ge, S. Zhang, F. Chen, H. Xing, Q. Ren, W. Fan, K. Zhao, Y. Hua, and J. Shi, “A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy,” J. Am. Chem. Soc. 135(35), 13041–13048 (2013).
[Crossref] [PubMed]

Zhang, X.

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

L. Liu, W. C. Law, K. T. Yong, I. Roy, H. Ding, F. Erogbogbo, X. Zhang, and P. N. Prasad, “Multimodal imaging probes based on Gd-DOTA conjugated quantum dot nanomicelles,” Analyst (Lond.) 136(9), 1881–1886 (2011).
[Crossref] [PubMed]

Zhao, K.

Q. Xiao, X. Zheng, W. Bu, W. Ge, S. Zhang, F. Chen, H. Xing, Q. Ren, W. Fan, K. Zhao, Y. Hua, and J. Shi, “A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy,” J. Am. Chem. Soc. 135(35), 13041–13048 (2013).
[Crossref] [PubMed]

Zhao, W.

W.-C. Law, K.-T. Yong, I. Roy, H. Ding, R. Hu, W. Zhao, and P. N. Prasad, “Aqueous-phase synthesis of highly luminescent cdte/znte core/shell quantum dots optimized for targeted bioimaging,” Small 5(11), 1302–1310 (2009).
[Crossref] [PubMed]

Zheng, X.

Q. Xiao, X. Zheng, W. Bu, W. Ge, S. Zhang, F. Chen, H. Xing, Q. Ren, W. Fan, K. Zhao, Y. Hua, and J. Shi, “A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy,” J. Am. Chem. Soc. 135(35), 13041–13048 (2013).
[Crossref] [PubMed]

Zhu, D.

X. Liu, C. Lee, W.-C. Law, D. Zhu, M. Liu, M. Jeon, J. Kim, P. N. Prasad, C. Kim, and M. T. Swihart, “Au-Cu2-xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging,” Nano Lett. 13(9), 4333–4339 (2013).
[Crossref] [PubMed]

Zhu, J.

J. Liu, W.-C. Law, J. Liu, R. Hu, L. Liu, J. Zhu, H. Chen, J. Wang, Y. Hu, L. Ye, and K.-T. Yong, “Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice,” RSC Advances 3(6), 1768–1773 (2013).
[Crossref]

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

ACS Nano (2)

G. J. Stasiuk, S. Tamang, D. Imbert, C. Poillot, M. Giardiello, C. Tisseyre, E. L. Barbier, P. H. Fries, M. de Waard, P. Reiss, and M. Mazzanti, “Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents,” ACS Nano 5(10), 8193–8201 (2011).
[Crossref] [PubMed]

G. Chen, T. Y. Ohulchanskyy, S. Liu, W. C. Law, F. Wu, M. T. Swihart, H. Agren, and P. N. Prasad, “Core/shell NaGdF4:Nd3+/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications,” ACS Nano 6(4), 2969–2977 (2012).
[Crossref] [PubMed]

Anal. Chem. (1)

L. J. Sang and H. F. Wang, “Aminophenylboronic-acid-conjugated polyacrylic acid-Mn-doped ZnS quantum dot for highly sensitive discrimination of glycoproteins,” Anal. Chem. 86(12), 5706–5712 (2014).
[Crossref] [PubMed]

Analyst (Lond.) (1)

L. Liu, W. C. Law, K. T. Yong, I. Roy, H. Ding, F. Erogbogbo, X. Zhang, and P. N. Prasad, “Multimodal imaging probes based on Gd-DOTA conjugated quantum dot nanomicelles,” Analyst (Lond.) 136(9), 1881–1886 (2011).
[Crossref] [PubMed]

Angew. Chem. Int. Ed. Engl. (1)

S. K. Panda, S. G. Hickey, H. V. Demir, and A. Eychmüller, “Bright white-light emitting manganese and copper co-doped ZnSe quantum dots,” Angew. Chem. Int. Ed. Engl. 50(19), 4432–4436 (2011).
[Crossref] [PubMed]

ECS J. Solid State Sci. Technol. (1)

T. Jin and Y. Imamura, “Applications of highly bright pbs quantum dots to non-invasive near-infrared fluorescence imaging in the second optical window,” ECS J. Solid State Sci. Technol. 5(1), R3138–R3145 (2016).
[Crossref]

Int. J. Nanomedicine (1)

L. Damalakiene, V. Karabanovas, S. Bagdonas, M. Valius, and R. Rotomskis, “Intracellular distribution of nontargeted quantum dots after natural uptake and microinjection,” Int. J. Nanomedicine 8(10), 555–568 (2013).
[Crossref] [PubMed]

J. Am. Chem. Soc. (2)

B. E. Rolfe, I. Blakey, O. Squires, H. Peng, N. R. B. Boase, C. Alexander, P. G. Parsons, G. M. Boyle, A. K. Whittaker, and K. J. Thurecht, “Multimodal polymer nanoparticles with combined 19f magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo,” J. Am. Chem. Soc. 136(6), 2413–2419 (2014).
[Crossref] [PubMed]

Q. Xiao, X. Zheng, W. Bu, W. Ge, S. Zhang, F. Chen, H. Xing, Q. Ren, W. Fan, K. Zhao, Y. Hua, and J. Shi, “A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy,” J. Am. Chem. Soc. 135(35), 13041–13048 (2013).
[Crossref] [PubMed]

Nano Lett. (1)

X. Liu, C. Lee, W.-C. Law, D. Zhu, M. Liu, M. Jeon, J. Kim, P. N. Prasad, C. Kim, and M. T. Swihart, “Au-Cu2-xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging,” Nano Lett. 13(9), 4333–4339 (2013).
[Crossref] [PubMed]

Nanoscale (1)

G. Sitbon, S. Bouccara, M. Tasso, A. Francois, L. Bezdetnaya, F. Marchal, M. Beaumont, and T. Pons, “Multimodal Mn-doped I-III-VI quantum dots for near infrared fluorescence and magnetic resonance imaging: from synthesis to in vivo application,” Nanoscale 6(15), 9264–9272 (2014).
[Crossref] [PubMed]

Nanotechnology (1)

K.-T. Yong, “Mn-doped near-infrared quantum dots as multimodal targeted probes for pancreatic cancer imaging,” Nanotechnology 20(1), 015102 (2009).
[Crossref] [PubMed]

Nat. Biotechnol. (2)

A. Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, B. Wiedenmann, and C. Grötzinger, “Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands,” Nat. Biotechnol. 19(4), 327–331 (2001).
[Crossref] [PubMed]

S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, and J. V. Frangioni, “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nat. Biotechnol. 22(1), 93–97 (2004).
[Crossref] [PubMed]

Nat. Nanotechnol. (1)

L. Ye, K.-T. Yong, L. Liu, I. Roy, R. Hu, J. Zhu, H. Cai, W.-C. Law, J. Liu, K. Wang, J. Liu, Y. Liu, Y. Hu, X. Zhang, M. T. Swihart, and P. N. Prasad, “A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots,” Nat. Nanotechnol. 7(7), 453–458 (2012).
[Crossref] [PubMed]

Opt. Express (1)

Part. Part. Syst. Charact. (1)

L. Turyanska, F. Moro, A. N. Knott, M. W. Fay, T. D. Bradshaw, and A. Patanè, “Paramagnetic, near-infrared fluorescent mn-doped pbs colloidal nanocrystals,” Part. Part. Syst. Charact. 30(11), 945–949 (2013).
[Crossref]

RSC Advances (1)

J. Liu, W.-C. Law, J. Liu, R. Hu, L. Liu, J. Zhu, H. Chen, J. Wang, Y. Hu, L. Ye, and K.-T. Yong, “Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice,” RSC Advances 3(6), 1768–1773 (2013).
[Crossref]

Small (1)

W.-C. Law, K.-T. Yong, I. Roy, H. Ding, R. Hu, W. Zhao, and P. N. Prasad, “Aqueous-phase synthesis of highly luminescent cdte/znte core/shell quantum dots optimized for targeted bioimaging,” Small 5(11), 1302–1310 (2009).
[Crossref] [PubMed]

Other (1)

P. N. Prasad, Introduction to Nanomedicine and Nanobioengineering, (Wiley-Interscience, 2013).

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Figures (7)

Fig. 1
Fig. 1 TEM image of Mn:NIR-QDs dispersed in (a) organic solvent and (b) aqueous media. (c) XRD, (d) EDX, (e) absorption, emission (excitation: 488nm) and (f) lifetime (excitation: 650nm) profile of Mn:NIR-QDs.
Fig. 2
Fig. 2 (a) Hysteresis curve of Mn:NIR-QDs obtained at room temperature (25°C); (b) R1 relaxivity of Mn:NIR-QD nanomicelles in water.
Fig. 3
Fig. 3 Cell images of macrophages treated with NIR-emitting Mn:NIR-QDs.
Fig. 4
Fig. 4 Cytotoxicity studies of cells treated with the Mn:NIR-QDs. MTS assays illustrating percentage cell viability (compared to nontreated cells being arbitrarily assigned 100% viability) upon exposing the cells to different concentrations of Mn:NIR-QD nanomicelles for 24 and 48 hours.
Fig. 5
Fig. 5 Time-dependent in vivo imaging of Panc-1 tumor bearing mice (right shoulder, indicated by yellow arrow) treated with RGD-conjugated (upper panel) and unconjugated (lower panel) Mn:NIR-QD nanomicelles. All images were acquired under the same conditions. Inset is the luminescence spectrum of Mn:NIR-QD.
Fig. 6
Fig. 6 (a) Luminescence images of major organs and tumors harvested at 24 hr post injection. (b) SLN imaging at 45 minutes post injection of Mn:NIR-QD into left paw. Inset is the luminescence spectrum of Mn:NIR-QD.
Fig. 7
Fig. 7 Histological studies (Objective: 40x) on the major organs of the Mn:NIR-QD injected mice after 3 weeks. No damages of tissues have been found.

Equations (1)

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