Abstract

Combining anatomical information from high resolution imaging modalities to guide near-infrared spectral tomography (NIRST) is an efficient strategy for improving the quality of the reconstructed spectral images. A new approach for incorporating image information directly into the inversion matrix regularization was examined using Direct Regularization from Images (DRI), which encodes the gray-scale data into the NIRST image reconstruction problem. This process has the benefit of eliminating user intervention such as image segmentation of distinct regions. Specifically, the Dynamic Contrast Enhanced Magnetic Resonance (DCE-MR) image intensity value differences within the anatomical image were used to implement an exponentially-weighted regularization function between the image pixels. The algorithm was validated using simulated reconstructions with noise, and the results showed that spatial resolution and robustness of the reconstructed images were significantly improved by appropriate choice of the regularization weight parameters. The proposed approach was also tested on in vivo breast data acquired in a recent clinical trial combining NIRST / MRI for cancer tumor characterization. Relative to the standard “no priors” diffuse recovery, the contrast of the tumor to the normal surrounding tissue increased from 2.4 to 3.6, and the difference between the tumor size segmented from DCE-MR images and reconstructed optical images decreased from 18% to 6%, while there was an overall decrease in surface artifacts.

© 2015 Optical Society of America

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    [Crossref] [PubMed]
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    [Crossref]
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    [Crossref] [PubMed]
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  24. B. W. Pogue, S. C. Davis, X. Song, B. A. Brooksby, H. Dehghani, and K. D. Paulsen, “Image analysis methods for diffuse optical tomography,” J. Biomed. Opt. 11(3), 033001 (2006).
    [Crossref] [PubMed]
  25. H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: Algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  28. M. A. Mastanduno, J. Xu, F. El-Ghussein, S. Jiang, H. Yin, Y. Zhao, K. E. Michaelsen, K. Wang, F. Ren, B. W. Pogue, and K. D. Paulsen, “Sensitivity of MRI-guided near-infrared spectroscopy clinical breast exam data and its impact on diagnostic performance,” Biomed. Opt. Express 5(9), 3103–3115 (2014).
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    [Crossref] [PubMed]

2014 (2)

M. A. Mastanduno, F. El-Ghussein, S. Jiang, R. Diflorio-Alexander, X. Junqing, Y. Hong, B. W. Pogue, and K. D. Paulsen, “Adaptable near-infrared spectroscopy fiber array for improved coupling to different breast sizes during clinical MRI,” Acad. Radiol. 21(2), 141–150 (2014).
[Crossref] [PubMed]

M. A. Mastanduno, J. Xu, F. El-Ghussein, S. Jiang, H. Yin, Y. Zhao, K. E. Michaelsen, K. Wang, F. Ren, B. W. Pogue, and K. D. Paulsen, “Sensitivity of MRI-guided near-infrared spectroscopy clinical breast exam data and its impact on diagnostic performance,” Biomed. Opt. Express 5(9), 3103–3115 (2014).
[Crossref] [PubMed]

2013 (2)

F. El-Ghussein, M. A. Mastanduno, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging,” J. Biomed. Opt. 19(1), 011010 (2013).
[Crossref] [PubMed]

R. W. Holt, S. Davis, and B. W. Pogue, “Regularization functional semi-automated incorporation of anatomical prior information in image-guided fluorescence tomography,” Opt. Lett. 38(14), 2407–2409 (2013).
[Crossref] [PubMed]

2012 (2)

C. B. Shaw and P. K. Yalavarthy, “Prior image-constrained ℓ(1)-norm-based reconstruction method for effective usage of structural information in diffuse optical tomography,” Opt. Lett. 37(20), 4353–4355 (2012).
[Crossref] [PubMed]

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

2011 (1)

Y. Lin, D. Thayer, O. Nalcioglu, and G. Gulsen, “Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography,” J. Biomed. Opt. 16(10), 106015 (2011).
[Crossref] [PubMed]

2010 (1)

2009 (3)

Q. Fang, S. A. Carp, J. Selb, G. Boverman, Q. Zhang, D. B. Kopans, R. H. Moore, E. L. Miller, D. H. Brooks, and D. A. Boas, “Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression,” IEEE Trans. Med. Imaging 28(1), 30–42 (2009).
[Crossref] [PubMed]

P. Hiltunen, S. J. Prince, and S. Arridge, “A combined reconstruction-classification method for diffuse optical tomography,” Phys. Med. Biol. 54(21), 6457–6476 (2009).
[Crossref] [PubMed]

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: Algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[Crossref] [PubMed]

2008 (1)

2007 (3)

2006 (2)

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. W. Pogue, S. C. Davis, X. Song, B. A. Brooksby, H. Dehghani, and K. D. Paulsen, “Image analysis methods for diffuse optical tomography,” J. Biomed. Opt. 11(3), 033001 (2006).
[Crossref] [PubMed]

2005 (4)

Q. Zhang, T. J. Brukilacchio, A. Li, J. J. Stott, T. Chaves, E. Hillman, T. Wu, M. Chorlton, E. Rafferty, R. H. Moore, D. B. Kopans, and D. A. Boas, “Coregistered tomographic x-ray and optical breast imaging: initial results,” J. Biomed. Opt. 10(2), 024033 (2005).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

M. Guven, B. Yazici, X. Intes, and B. Chance, “Diffuse optical tomography with a priori anatomical information,” Phys. Med. Biol. 50(12), 2837–2858 (2005).
[Crossref] [PubMed]

A. Li, G. Boverman, Y. Zhang, D. Brooks, E. L. Miller, M. E. Kilmer, Q. Zhang, E. M. Hillman, and D. A. Boas, “Optimal linear inverse solution with multiple priors in diffuse optical tomography,” Appl. Opt. 44(10), 1948–1956 (2005).
[Crossref] [PubMed]

2003 (3)

B. W. Pogue, H. Zhu, C. Nwaigwe, T. O. McBride, U. L. Osterberg, K. D. Paulsen, and J. F. Dunn, “Hemoglobin imaging with hybrid magnetic resonance and near-infrared diffuse tomography,” Adv. Exp. Med. Biol. 530, 215–224 (2003).
[Crossref] [PubMed]

Q. Zhu, N. Chen, and S. H. Kurtzman, “Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound,” Opt. Lett. 28(5), 337–339 (2003).
[Crossref] [PubMed]

B. A. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, “Near-infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9(2), 199–209 (2003).
[Crossref]

2002 (2)

B. W. Pogue, X. Song, T. D. Tosteson, T. O. McBride, S. Jiang, and K. D. Paulsen, “Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part I--Theory and simulations,” IEEE Trans. Med. Imaging 21(7), 755–763 (2002).
[Crossref] [PubMed]

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4(4), 347–354 (2002).
[Crossref] [PubMed]

2001 (1)

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
[Crossref]

1999 (1)

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15(2), R41–R93 (1999).
[Crossref]

Arridge, S.

P. Hiltunen, S. J. Prince, and S. Arridge, “A combined reconstruction-classification method for diffuse optical tomography,” Phys. Med. Biol. 54(21), 6457–6476 (2009).
[Crossref] [PubMed]

Arridge, S. R.

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15(2), R41–R93 (1999).
[Crossref]

Azar, F. S.

F. S. Azar, K. Lee, A. Khamene, R. Choe, A. Corlu, S. D. Konecky, F. Sauer, and A. G. Yodh, “Standardized platform for coregistration of nonconcurrent diffuse optical and magnetic resonance breast images obtained in different geometries,” J. Biomed. Opt. 12(5), 051902 (2007).
[Crossref] [PubMed]

Boas, D. A.

Q. Fang, R. H. Moore, D. B. Kopans, and D. A. Boas, “Compositional-prior-guided image reconstruction algorithm for multi-modality imaging,” Biomed. Opt. Express 1(1), 223–235 (2010).
[Crossref] [PubMed]

Q. Fang, S. A. Carp, J. Selb, G. Boverman, Q. Zhang, D. B. Kopans, R. H. Moore, E. L. Miller, D. H. Brooks, and D. A. Boas, “Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression,” IEEE Trans. Med. Imaging 28(1), 30–42 (2009).
[Crossref] [PubMed]

A. Li, G. Boverman, Y. Zhang, D. Brooks, E. L. Miller, M. E. Kilmer, Q. Zhang, E. M. Hillman, and D. A. Boas, “Optimal linear inverse solution with multiple priors in diffuse optical tomography,” Appl. Opt. 44(10), 1948–1956 (2005).
[Crossref] [PubMed]

Q. Zhang, T. J. Brukilacchio, A. Li, J. J. Stott, T. Chaves, E. Hillman, T. Wu, M. Chorlton, E. Rafferty, R. H. Moore, D. B. Kopans, and D. A. Boas, “Coregistered tomographic x-ray and optical breast imaging: initial results,” J. Biomed. Opt. 10(2), 024033 (2005).
[Crossref] [PubMed]

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
[Crossref]

Borden, M. A.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Boverman, G.

Q. Fang, S. A. Carp, J. Selb, G. Boverman, Q. Zhang, D. B. Kopans, R. H. Moore, E. L. Miller, D. H. Brooks, and D. A. Boas, “Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression,” IEEE Trans. Med. Imaging 28(1), 30–42 (2009).
[Crossref] [PubMed]

A. Li, G. Boverman, Y. Zhang, D. Brooks, E. L. Miller, M. E. Kilmer, Q. Zhang, E. M. Hillman, and D. A. Boas, “Optimal linear inverse solution with multiple priors in diffuse optical tomography,” Appl. Opt. 44(10), 1948–1956 (2005).
[Crossref] [PubMed]

Brooks, D.

Brooks, D. H.

Q. Fang, S. A. Carp, J. Selb, G. Boverman, Q. Zhang, D. B. Kopans, R. H. Moore, E. L. Miller, D. H. Brooks, and D. A. Boas, “Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression,” IEEE Trans. Med. Imaging 28(1), 30–42 (2009).
[Crossref] [PubMed]

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
[Crossref]

Brooksby, B.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

Brooksby, B. A.

B. W. Pogue, S. C. Davis, X. Song, B. A. Brooksby, H. Dehghani, and K. D. Paulsen, “Image analysis methods for diffuse optical tomography,” J. Biomed. Opt. 11(3), 033001 (2006).
[Crossref] [PubMed]

B. A. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, “Near-infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9(2), 199–209 (2003).
[Crossref]

Brukilacchio, T. J.

Q. Zhang, T. J. Brukilacchio, A. Li, J. J. Stott, T. Chaves, E. Hillman, T. Wu, M. Chorlton, E. Rafferty, R. H. Moore, D. B. Kopans, and D. A. Boas, “Coregistered tomographic x-ray and optical breast imaging: initial results,” J. Biomed. Opt. 10(2), 024033 (2005).
[Crossref] [PubMed]

Carp, S. A.

Q. Fang, S. A. Carp, J. Selb, G. Boverman, Q. Zhang, D. B. Kopans, R. H. Moore, E. L. Miller, D. H. Brooks, and D. A. Boas, “Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression,” IEEE Trans. Med. Imaging 28(1), 30–42 (2009).
[Crossref] [PubMed]

Carpenter, C. M.

Chance, B.

M. Guven, B. Yazici, X. Intes, and B. Chance, “Diffuse optical tomography with a priori anatomical information,” Phys. Med. Biol. 50(12), 2837–2858 (2005).
[Crossref] [PubMed]

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4(4), 347–354 (2002).
[Crossref] [PubMed]

Chaves, T.

Q. Zhang, T. J. Brukilacchio, A. Li, J. J. Stott, T. Chaves, E. Hillman, T. Wu, M. Chorlton, E. Rafferty, R. H. Moore, D. B. Kopans, and D. A. Boas, “Coregistered tomographic x-ray and optical breast imaging: initial results,” J. Biomed. Opt. 10(2), 024033 (2005).
[Crossref] [PubMed]

Chen, N.

Choe, R.

F. S. Azar, K. Lee, A. Khamene, R. Choe, A. Corlu, S. D. Konecky, F. Sauer, and A. G. Yodh, “Standardized platform for coregistration of nonconcurrent diffuse optical and magnetic resonance breast images obtained in different geometries,” J. Biomed. Opt. 12(5), 051902 (2007).
[Crossref] [PubMed]

Chorlton, M.

Q. Zhang, T. J. Brukilacchio, A. Li, J. J. Stott, T. Chaves, E. Hillman, T. Wu, M. Chorlton, E. Rafferty, R. H. Moore, D. B. Kopans, and D. A. Boas, “Coregistered tomographic x-ray and optical breast imaging: initial results,” J. Biomed. Opt. 10(2), 024033 (2005).
[Crossref] [PubMed]

Corlu, A.

F. S. Azar, K. Lee, A. Khamene, R. Choe, A. Corlu, S. D. Konecky, F. Sauer, and A. G. Yodh, “Standardized platform for coregistration of nonconcurrent diffuse optical and magnetic resonance breast images obtained in different geometries,” J. Biomed. Opt. 12(5), 051902 (2007).
[Crossref] [PubMed]

Davis, S.

Davis, S. C.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: Algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[Crossref] [PubMed]

B. W. Pogue, S. C. Davis, X. Song, B. A. Brooksby, H. Dehghani, and K. D. Paulsen, “Image analysis methods for diffuse optical tomography,” J. Biomed. Opt. 11(3), 033001 (2006).
[Crossref] [PubMed]

Dehghani, H.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: Algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[Crossref] [PubMed]

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, C. M. Carpenter, S. Jiang, and K. D. Paulsen, “Structural information within regularization matrices improves near infrared diffuse optical tomography,” Opt. Express 15(13), 8043–8058 (2007).
[Crossref] [PubMed]

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, “Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size,” Opt. Lett. 32(8), 933–935 (2007).
[Crossref] [PubMed]

B. W. Pogue, S. C. Davis, X. Song, B. A. Brooksby, H. Dehghani, and K. D. Paulsen, “Image analysis methods for diffuse optical tomography,” J. Biomed. Opt. 11(3), 033001 (2006).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

B. A. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, “Near-infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9(2), 199–209 (2003).
[Crossref]

Diflorio-Alexander, R.

M. A. Mastanduno, F. El-Ghussein, S. Jiang, R. Diflorio-Alexander, X. Junqing, Y. Hong, B. W. Pogue, and K. D. Paulsen, “Adaptable near-infrared spectroscopy fiber array for improved coupling to different breast sizes during clinical MRI,” Acad. Radiol. 21(2), 141–150 (2014).
[Crossref] [PubMed]

DiMarzio, C. A.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
[Crossref]

Dunn, J. F.

B. W. Pogue, H. Zhu, C. Nwaigwe, T. O. McBride, U. L. Osterberg, K. D. Paulsen, and J. F. Dunn, “Hemoglobin imaging with hybrid magnetic resonance and near-infrared diffuse tomography,” Adv. Exp. Med. Biol. 530, 215–224 (2003).
[Crossref] [PubMed]

Eames, M. E.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: Algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[Crossref] [PubMed]

El-Ghussein, F.

M. A. Mastanduno, F. El-Ghussein, S. Jiang, R. Diflorio-Alexander, X. Junqing, Y. Hong, B. W. Pogue, and K. D. Paulsen, “Adaptable near-infrared spectroscopy fiber array for improved coupling to different breast sizes during clinical MRI,” Acad. Radiol. 21(2), 141–150 (2014).
[Crossref] [PubMed]

M. A. Mastanduno, J. Xu, F. El-Ghussein, S. Jiang, H. Yin, Y. Zhao, K. E. Michaelsen, K. Wang, F. Ren, B. W. Pogue, and K. D. Paulsen, “Sensitivity of MRI-guided near-infrared spectroscopy clinical breast exam data and its impact on diagnostic performance,” Biomed. Opt. Express 5(9), 3103–3115 (2014).
[Crossref] [PubMed]

F. El-Ghussein, M. A. Mastanduno, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging,” J. Biomed. Opt. 19(1), 011010 (2013).
[Crossref] [PubMed]

Fang, Q.

Q. Fang, R. H. Moore, D. B. Kopans, and D. A. Boas, “Compositional-prior-guided image reconstruction algorithm for multi-modality imaging,” Biomed. Opt. Express 1(1), 223–235 (2010).
[Crossref] [PubMed]

Q. Fang, S. A. Carp, J. Selb, G. Boverman, Q. Zhang, D. B. Kopans, R. H. Moore, E. L. Miller, D. H. Brooks, and D. A. Boas, “Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression,” IEEE Trans. Med. Imaging 28(1), 30–42 (2009).
[Crossref] [PubMed]

Flexman, M. L.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Forero, J.

Gander, J. W.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Gaudette, R. J.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
[Crossref]

Gulsen, G.

Y. Lin, D. Thayer, O. Nalcioglu, and G. Gulsen, “Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography,” J. Biomed. Opt. 16(10), 106015 (2011).
[Crossref] [PubMed]

Guven, M.

M. Guven, B. Yazici, X. Intes, and B. Chance, “Diffuse optical tomography with a priori anatomical information,” Phys. Med. Biol. 50(12), 2837–2858 (2005).
[Crossref] [PubMed]

Hernandez, S. L.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Hielscher, A. H.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Hillman, E.

Q. Zhang, T. J. Brukilacchio, A. Li, J. J. Stott, T. Chaves, E. Hillman, T. Wu, M. Chorlton, E. Rafferty, R. H. Moore, D. B. Kopans, and D. A. Boas, “Coregistered tomographic x-ray and optical breast imaging: initial results,” J. Biomed. Opt. 10(2), 024033 (2005).
[Crossref] [PubMed]

Hillman, E. M.

Hiltunen, P.

P. Hiltunen, S. J. Prince, and S. Arridge, “A combined reconstruction-classification method for diffuse optical tomography,” Phys. Med. Biol. 54(21), 6457–6476 (2009).
[Crossref] [PubMed]

Holt, R. W.

Hong, Y.

M. A. Mastanduno, F. El-Ghussein, S. Jiang, R. Diflorio-Alexander, X. Junqing, Y. Hong, B. W. Pogue, and K. D. Paulsen, “Adaptable near-infrared spectroscopy fiber array for improved coupling to different breast sizes during clinical MRI,” Acad. Radiol. 21(2), 141–150 (2014).
[Crossref] [PubMed]

Huang, J.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Intes, X.

M. Guven, B. Yazici, X. Intes, and B. Chance, “Diffuse optical tomography with a priori anatomical information,” Phys. Med. Biol. 50(12), 2837–2858 (2005).
[Crossref] [PubMed]

Jiang, S.

M. A. Mastanduno, F. El-Ghussein, S. Jiang, R. Diflorio-Alexander, X. Junqing, Y. Hong, B. W. Pogue, and K. D. Paulsen, “Adaptable near-infrared spectroscopy fiber array for improved coupling to different breast sizes during clinical MRI,” Acad. Radiol. 21(2), 141–150 (2014).
[Crossref] [PubMed]

M. A. Mastanduno, J. Xu, F. El-Ghussein, S. Jiang, H. Yin, Y. Zhao, K. E. Michaelsen, K. Wang, F. Ren, B. W. Pogue, and K. D. Paulsen, “Sensitivity of MRI-guided near-infrared spectroscopy clinical breast exam data and its impact on diagnostic performance,” Biomed. Opt. Express 5(9), 3103–3115 (2014).
[Crossref] [PubMed]

F. El-Ghussein, M. A. Mastanduno, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging,” J. Biomed. Opt. 19(1), 011010 (2013).
[Crossref] [PubMed]

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, “Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size,” Opt. Lett. 32(8), 933–935 (2007).
[Crossref] [PubMed]

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, C. M. Carpenter, S. Jiang, and K. D. Paulsen, “Structural information within regularization matrices improves near infrared diffuse optical tomography,” Opt. Express 15(13), 8043–8058 (2007).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

B. W. Pogue, X. Song, T. D. Tosteson, T. O. McBride, S. Jiang, and K. D. Paulsen, “Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part I--Theory and simulations,” IEEE Trans. Med. Imaging 21(7), 755–763 (2002).
[Crossref] [PubMed]

Johung, T. B.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Junqing, X.

M. A. Mastanduno, F. El-Ghussein, S. Jiang, R. Diflorio-Alexander, X. Junqing, Y. Hong, B. W. Pogue, and K. D. Paulsen, “Adaptable near-infrared spectroscopy fiber array for improved coupling to different breast sizes during clinical MRI,” Acad. Radiol. 21(2), 141–150 (2014).
[Crossref] [PubMed]

Kandel, J. J.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Kaufman, P. A.

Khamene, A.

F. S. Azar, K. Lee, A. Khamene, R. Choe, A. Corlu, S. D. Konecky, F. Sauer, and A. G. Yodh, “Standardized platform for coregistration of nonconcurrent diffuse optical and magnetic resonance breast images obtained in different geometries,” J. Biomed. Opt. 12(5), 051902 (2007).
[Crossref] [PubMed]

Kilmer, M.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
[Crossref]

Kilmer, M. E.

Kim, H. K.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Kogel, C.

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, “Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size,” Opt. Lett. 32(8), 933–935 (2007).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

Konecky, S. D.

F. S. Azar, K. Lee, A. Khamene, R. Choe, A. Corlu, S. D. Konecky, F. Sauer, and A. G. Yodh, “Standardized platform for coregistration of nonconcurrent diffuse optical and magnetic resonance breast images obtained in different geometries,” J. Biomed. Opt. 12(5), 051902 (2007).
[Crossref] [PubMed]

Kopans, D. B.

Q. Fang, R. H. Moore, D. B. Kopans, and D. A. Boas, “Compositional-prior-guided image reconstruction algorithm for multi-modality imaging,” Biomed. Opt. Express 1(1), 223–235 (2010).
[Crossref] [PubMed]

Q. Fang, S. A. Carp, J. Selb, G. Boverman, Q. Zhang, D. B. Kopans, R. H. Moore, E. L. Miller, D. H. Brooks, and D. A. Boas, “Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression,” IEEE Trans. Med. Imaging 28(1), 30–42 (2009).
[Crossref] [PubMed]

Q. Zhang, T. J. Brukilacchio, A. Li, J. J. Stott, T. Chaves, E. Hillman, T. Wu, M. Chorlton, E. Rafferty, R. H. Moore, D. B. Kopans, and D. A. Boas, “Coregistered tomographic x-ray and optical breast imaging: initial results,” J. Biomed. Opt. 10(2), 024033 (2005).
[Crossref] [PubMed]

Kurtzman, S. H.

Lampl, B. S.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Lee, K.

F. S. Azar, K. Lee, A. Khamene, R. Choe, A. Corlu, S. D. Konecky, F. Sauer, and A. G. Yodh, “Standardized platform for coregistration of nonconcurrent diffuse optical and magnetic resonance breast images obtained in different geometries,” J. Biomed. Opt. 12(5), 051902 (2007).
[Crossref] [PubMed]

Li, A.

A. Li, G. Boverman, Y. Zhang, D. Brooks, E. L. Miller, M. E. Kilmer, Q. Zhang, E. M. Hillman, and D. A. Boas, “Optimal linear inverse solution with multiple priors in diffuse optical tomography,” Appl. Opt. 44(10), 1948–1956 (2005).
[Crossref] [PubMed]

Q. Zhang, T. J. Brukilacchio, A. Li, J. J. Stott, T. Chaves, E. Hillman, T. Wu, M. Chorlton, E. Rafferty, R. H. Moore, D. B. Kopans, and D. A. Boas, “Coregistered tomographic x-ray and optical breast imaging: initial results,” J. Biomed. Opt. 10(2), 024033 (2005).
[Crossref] [PubMed]

Lin, Y.

Y. Lin, D. Thayer, O. Nalcioglu, and G. Gulsen, “Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography,” J. Biomed. Opt. 16(10), 106015 (2011).
[Crossref] [PubMed]

Mastanduno, M. A.

M. A. Mastanduno, F. El-Ghussein, S. Jiang, R. Diflorio-Alexander, X. Junqing, Y. Hong, B. W. Pogue, and K. D. Paulsen, “Adaptable near-infrared spectroscopy fiber array for improved coupling to different breast sizes during clinical MRI,” Acad. Radiol. 21(2), 141–150 (2014).
[Crossref] [PubMed]

M. A. Mastanduno, J. Xu, F. El-Ghussein, S. Jiang, H. Yin, Y. Zhao, K. E. Michaelsen, K. Wang, F. Ren, B. W. Pogue, and K. D. Paulsen, “Sensitivity of MRI-guided near-infrared spectroscopy clinical breast exam data and its impact on diagnostic performance,” Biomed. Opt. Express 5(9), 3103–3115 (2014).
[Crossref] [PubMed]

F. El-Ghussein, M. A. Mastanduno, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging,” J. Biomed. Opt. 19(1), 011010 (2013).
[Crossref] [PubMed]

McBride, T. O.

B. W. Pogue, H. Zhu, C. Nwaigwe, T. O. McBride, U. L. Osterberg, K. D. Paulsen, and J. F. Dunn, “Hemoglobin imaging with hybrid magnetic resonance and near-infrared diffuse tomography,” Adv. Exp. Med. Biol. 530, 215–224 (2003).
[Crossref] [PubMed]

B. W. Pogue, X. Song, T. D. Tosteson, T. O. McBride, S. Jiang, and K. D. Paulsen, “Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part I--Theory and simulations,” IEEE Trans. Med. Imaging 21(7), 755–763 (2002).
[Crossref] [PubMed]

Michaelsen, K. E.

Miller, E. L.

Q. Fang, S. A. Carp, J. Selb, G. Boverman, Q. Zhang, D. B. Kopans, R. H. Moore, E. L. Miller, D. H. Brooks, and D. A. Boas, “Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression,” IEEE Trans. Med. Imaging 28(1), 30–42 (2009).
[Crossref] [PubMed]

A. Li, G. Boverman, Y. Zhang, D. Brooks, E. L. Miller, M. E. Kilmer, Q. Zhang, E. M. Hillman, and D. A. Boas, “Optimal linear inverse solution with multiple priors in diffuse optical tomography,” Appl. Opt. 44(10), 1948–1956 (2005).
[Crossref] [PubMed]

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
[Crossref]

Moore, R. H.

Q. Fang, R. H. Moore, D. B. Kopans, and D. A. Boas, “Compositional-prior-guided image reconstruction algorithm for multi-modality imaging,” Biomed. Opt. Express 1(1), 223–235 (2010).
[Crossref] [PubMed]

Q. Fang, S. A. Carp, J. Selb, G. Boverman, Q. Zhang, D. B. Kopans, R. H. Moore, E. L. Miller, D. H. Brooks, and D. A. Boas, “Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression,” IEEE Trans. Med. Imaging 28(1), 30–42 (2009).
[Crossref] [PubMed]

Q. Zhang, T. J. Brukilacchio, A. Li, J. J. Stott, T. Chaves, E. Hillman, T. Wu, M. Chorlton, E. Rafferty, R. H. Moore, D. B. Kopans, and D. A. Boas, “Coregistered tomographic x-ray and optical breast imaging: initial results,” J. Biomed. Opt. 10(2), 024033 (2005).
[Crossref] [PubMed]

Nalcioglu, O.

Y. Lin, D. Thayer, O. Nalcioglu, and G. Gulsen, “Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography,” J. Biomed. Opt. 16(10), 106015 (2011).
[Crossref] [PubMed]

Ntziachristos, V.

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4(4), 347–354 (2002).
[Crossref] [PubMed]

Nwaigwe, C.

B. W. Pogue, H. Zhu, C. Nwaigwe, T. O. McBride, U. L. Osterberg, K. D. Paulsen, and J. F. Dunn, “Hemoglobin imaging with hybrid magnetic resonance and near-infrared diffuse tomography,” Adv. Exp. Med. Biol. 530, 215–224 (2003).
[Crossref] [PubMed]

Osterberg, U. L.

B. W. Pogue, H. Zhu, C. Nwaigwe, T. O. McBride, U. L. Osterberg, K. D. Paulsen, and J. F. Dunn, “Hemoglobin imaging with hybrid magnetic resonance and near-infrared diffuse tomography,” Adv. Exp. Med. Biol. 530, 215–224 (2003).
[Crossref] [PubMed]

Paulsen, K. D.

M. A. Mastanduno, F. El-Ghussein, S. Jiang, R. Diflorio-Alexander, X. Junqing, Y. Hong, B. W. Pogue, and K. D. Paulsen, “Adaptable near-infrared spectroscopy fiber array for improved coupling to different breast sizes during clinical MRI,” Acad. Radiol. 21(2), 141–150 (2014).
[Crossref] [PubMed]

M. A. Mastanduno, J. Xu, F. El-Ghussein, S. Jiang, H. Yin, Y. Zhao, K. E. Michaelsen, K. Wang, F. Ren, B. W. Pogue, and K. D. Paulsen, “Sensitivity of MRI-guided near-infrared spectroscopy clinical breast exam data and its impact on diagnostic performance,” Biomed. Opt. Express 5(9), 3103–3115 (2014).
[Crossref] [PubMed]

F. El-Ghussein, M. A. Mastanduno, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging,” J. Biomed. Opt. 19(1), 011010 (2013).
[Crossref] [PubMed]

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: Algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[Crossref] [PubMed]

C. M. Carpenter, S. Srinivasan, B. W. Pogue, and K. D. Paulsen, “Methodology development for three-dimensional MR-guided near infrared spectroscopy of breast tumors,” Opt. Express 16(22), 17903–17914 (2008).
[Crossref] [PubMed]

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, “Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size,” Opt. Lett. 32(8), 933–935 (2007).
[Crossref] [PubMed]

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, C. M. Carpenter, S. Jiang, and K. D. Paulsen, “Structural information within regularization matrices improves near infrared diffuse optical tomography,” Opt. Express 15(13), 8043–8058 (2007).
[Crossref] [PubMed]

B. W. Pogue, S. C. Davis, X. Song, B. A. Brooksby, H. Dehghani, and K. D. Paulsen, “Image analysis methods for diffuse optical tomography,” J. Biomed. Opt. 11(3), 033001 (2006).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

B. W. Pogue, H. Zhu, C. Nwaigwe, T. O. McBride, U. L. Osterberg, K. D. Paulsen, and J. F. Dunn, “Hemoglobin imaging with hybrid magnetic resonance and near-infrared diffuse tomography,” Adv. Exp. Med. Biol. 530, 215–224 (2003).
[Crossref] [PubMed]

B. A. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, “Near-infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9(2), 199–209 (2003).
[Crossref]

B. W. Pogue, X. Song, T. D. Tosteson, T. O. McBride, S. Jiang, and K. D. Paulsen, “Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part I--Theory and simulations,” IEEE Trans. Med. Imaging 21(7), 755–763 (2002).
[Crossref] [PubMed]

Pogue, B. W.

M. A. Mastanduno, F. El-Ghussein, S. Jiang, R. Diflorio-Alexander, X. Junqing, Y. Hong, B. W. Pogue, and K. D. Paulsen, “Adaptable near-infrared spectroscopy fiber array for improved coupling to different breast sizes during clinical MRI,” Acad. Radiol. 21(2), 141–150 (2014).
[Crossref] [PubMed]

M. A. Mastanduno, J. Xu, F. El-Ghussein, S. Jiang, H. Yin, Y. Zhao, K. E. Michaelsen, K. Wang, F. Ren, B. W. Pogue, and K. D. Paulsen, “Sensitivity of MRI-guided near-infrared spectroscopy clinical breast exam data and its impact on diagnostic performance,” Biomed. Opt. Express 5(9), 3103–3115 (2014).
[Crossref] [PubMed]

R. W. Holt, S. Davis, and B. W. Pogue, “Regularization functional semi-automated incorporation of anatomical prior information in image-guided fluorescence tomography,” Opt. Lett. 38(14), 2407–2409 (2013).
[Crossref] [PubMed]

F. El-Ghussein, M. A. Mastanduno, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging,” J. Biomed. Opt. 19(1), 011010 (2013).
[Crossref] [PubMed]

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: Algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[Crossref] [PubMed]

C. M. Carpenter, S. Srinivasan, B. W. Pogue, and K. D. Paulsen, “Methodology development for three-dimensional MR-guided near infrared spectroscopy of breast tumors,” Opt. Express 16(22), 17903–17914 (2008).
[Crossref] [PubMed]

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, C. M. Carpenter, S. Jiang, and K. D. Paulsen, “Structural information within regularization matrices improves near infrared diffuse optical tomography,” Opt. Express 15(13), 8043–8058 (2007).
[Crossref] [PubMed]

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, “Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size,” Opt. Lett. 32(8), 933–935 (2007).
[Crossref] [PubMed]

B. W. Pogue, S. C. Davis, X. Song, B. A. Brooksby, H. Dehghani, and K. D. Paulsen, “Image analysis methods for diffuse optical tomography,” J. Biomed. Opt. 11(3), 033001 (2006).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

B. W. Pogue, H. Zhu, C. Nwaigwe, T. O. McBride, U. L. Osterberg, K. D. Paulsen, and J. F. Dunn, “Hemoglobin imaging with hybrid magnetic resonance and near-infrared diffuse tomography,” Adv. Exp. Med. Biol. 530, 215–224 (2003).
[Crossref] [PubMed]

B. A. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, “Near-infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9(2), 199–209 (2003).
[Crossref]

B. W. Pogue, X. Song, T. D. Tosteson, T. O. McBride, S. Jiang, and K. D. Paulsen, “Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part I--Theory and simulations,” IEEE Trans. Med. Imaging 21(7), 755–763 (2002).
[Crossref] [PubMed]

Poplack, S. P.

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, “Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size,” Opt. Lett. 32(8), 933–935 (2007).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

Prince, S. J.

P. Hiltunen, S. J. Prince, and S. Arridge, “A combined reconstruction-classification method for diffuse optical tomography,” Phys. Med. Biol. 54(21), 6457–6476 (2009).
[Crossref] [PubMed]

Rafferty, E.

Q. Zhang, T. J. Brukilacchio, A. Li, J. J. Stott, T. Chaves, E. Hillman, T. Wu, M. Chorlton, E. Rafferty, R. H. Moore, D. B. Kopans, and D. A. Boas, “Coregistered tomographic x-ray and optical breast imaging: initial results,” J. Biomed. Opt. 10(2), 024033 (2005).
[Crossref] [PubMed]

Reichstein, A. R.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Ren, F.

Sauer, F.

F. S. Azar, K. Lee, A. Khamene, R. Choe, A. Corlu, S. D. Konecky, F. Sauer, and A. G. Yodh, “Standardized platform for coregistration of nonconcurrent diffuse optical and magnetic resonance breast images obtained in different geometries,” J. Biomed. Opt. 12(5), 051902 (2007).
[Crossref] [PubMed]

Schnall, M. D.

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4(4), 347–354 (2002).
[Crossref] [PubMed]

Selb, J.

Q. Fang, S. A. Carp, J. Selb, G. Boverman, Q. Zhang, D. B. Kopans, R. H. Moore, E. L. Miller, D. H. Brooks, and D. A. Boas, “Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression,” IEEE Trans. Med. Imaging 28(1), 30–42 (2009).
[Crossref] [PubMed]

Shaw, C. B.

Sirsi, S. R.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Song, X.

B. W. Pogue, S. C. Davis, X. Song, B. A. Brooksby, H. Dehghani, and K. D. Paulsen, “Image analysis methods for diffuse optical tomography,” J. Biomed. Opt. 11(3), 033001 (2006).
[Crossref] [PubMed]

B. W. Pogue, X. Song, T. D. Tosteson, T. O. McBride, S. Jiang, and K. D. Paulsen, “Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part I--Theory and simulations,” IEEE Trans. Med. Imaging 21(7), 755–763 (2002).
[Crossref] [PubMed]

Srinivasan, S.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: Algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[Crossref] [PubMed]

C. M. Carpenter, S. Srinivasan, B. W. Pogue, and K. D. Paulsen, “Methodology development for three-dimensional MR-guided near infrared spectroscopy of breast tumors,” Opt. Express 16(22), 17903–17914 (2008).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

Stott, J. J.

Q. Zhang, T. J. Brukilacchio, A. Li, J. J. Stott, T. Chaves, E. Hillman, T. Wu, M. Chorlton, E. Rafferty, R. H. Moore, D. B. Kopans, and D. A. Boas, “Coregistered tomographic x-ray and optical breast imaging: initial results,” J. Biomed. Opt. 10(2), 024033 (2005).
[Crossref] [PubMed]

Thayer, D.

Y. Lin, D. Thayer, O. Nalcioglu, and G. Gulsen, “Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography,” J. Biomed. Opt. 16(10), 106015 (2011).
[Crossref] [PubMed]

Tosteson, T. D.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. W. Pogue, X. Song, T. D. Tosteson, T. O. McBride, S. Jiang, and K. D. Paulsen, “Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part I--Theory and simulations,” IEEE Trans. Med. Imaging 21(7), 755–763 (2002).
[Crossref] [PubMed]

Vlachos, F.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Wang, A.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Wang, K.

Wang, X.

Weaver, J.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

Weaver, J. B.

Wells, W. A.

Wu, T.

Q. Zhang, T. J. Brukilacchio, A. Li, J. J. Stott, T. Chaves, E. Hillman, T. Wu, M. Chorlton, E. Rafferty, R. H. Moore, D. B. Kopans, and D. A. Boas, “Coregistered tomographic x-ray and optical breast imaging: initial results,” J. Biomed. Opt. 10(2), 024033 (2005).
[Crossref] [PubMed]

Xu, J.

Yalavarthy, P. K.

Yamashiro, D. J.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Yazici, B.

M. Guven, B. Yazici, X. Intes, and B. Chance, “Diffuse optical tomography with a priori anatomical information,” Phys. Med. Biol. 50(12), 2837–2858 (2005).
[Crossref] [PubMed]

Yin, H.

Yodh, A. G.

F. S. Azar, K. Lee, A. Khamene, R. Choe, A. Corlu, S. D. Konecky, F. Sauer, and A. G. Yodh, “Standardized platform for coregistration of nonconcurrent diffuse optical and magnetic resonance breast images obtained in different geometries,” J. Biomed. Opt. 12(5), 051902 (2007).
[Crossref] [PubMed]

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4(4), 347–354 (2002).
[Crossref] [PubMed]

Zhang, Q.

Q. Fang, S. A. Carp, J. Selb, G. Boverman, Q. Zhang, D. B. Kopans, R. H. Moore, E. L. Miller, D. H. Brooks, and D. A. Boas, “Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression,” IEEE Trans. Med. Imaging 28(1), 30–42 (2009).
[Crossref] [PubMed]

A. Li, G. Boverman, Y. Zhang, D. Brooks, E. L. Miller, M. E. Kilmer, Q. Zhang, E. M. Hillman, and D. A. Boas, “Optimal linear inverse solution with multiple priors in diffuse optical tomography,” Appl. Opt. 44(10), 1948–1956 (2005).
[Crossref] [PubMed]

Q. Zhang, T. J. Brukilacchio, A. Li, J. J. Stott, T. Chaves, E. Hillman, T. Wu, M. Chorlton, E. Rafferty, R. H. Moore, D. B. Kopans, and D. A. Boas, “Coregistered tomographic x-ray and optical breast imaging: initial results,” J. Biomed. Opt. 10(2), 024033 (2005).
[Crossref] [PubMed]

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
[Crossref]

Zhang, Y.

Zhao, Y.

Zhu, H.

B. W. Pogue, H. Zhu, C. Nwaigwe, T. O. McBride, U. L. Osterberg, K. D. Paulsen, and J. F. Dunn, “Hemoglobin imaging with hybrid magnetic resonance and near-infrared diffuse tomography,” Adv. Exp. Med. Biol. 530, 215–224 (2003).
[Crossref] [PubMed]

Zhu, Q.

Acad. Radiol. (1)

M. A. Mastanduno, F. El-Ghussein, S. Jiang, R. Diflorio-Alexander, X. Junqing, Y. Hong, B. W. Pogue, and K. D. Paulsen, “Adaptable near-infrared spectroscopy fiber array for improved coupling to different breast sizes during clinical MRI,” Acad. Radiol. 21(2), 141–150 (2014).
[Crossref] [PubMed]

Adv. Exp. Med. Biol. (1)

B. W. Pogue, H. Zhu, C. Nwaigwe, T. O. McBride, U. L. Osterberg, K. D. Paulsen, and J. F. Dunn, “Hemoglobin imaging with hybrid magnetic resonance and near-infrared diffuse tomography,” Adv. Exp. Med. Biol. 530, 215–224 (2003).
[Crossref] [PubMed]

Appl. Opt. (1)

Biomed. Opt. Express (2)

Commun. Numer. Methods Eng. (1)

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: Algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[Crossref] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (1)

B. A. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, “Near-infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9(2), 199–209 (2003).
[Crossref]

IEEE Signal Process. Mag. (1)

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
[Crossref]

IEEE Trans. Med. Imaging (2)

B. W. Pogue, X. Song, T. D. Tosteson, T. O. McBride, S. Jiang, and K. D. Paulsen, “Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part I--Theory and simulations,” IEEE Trans. Med. Imaging 21(7), 755–763 (2002).
[Crossref] [PubMed]

Q. Fang, S. A. Carp, J. Selb, G. Boverman, Q. Zhang, D. B. Kopans, R. H. Moore, E. L. Miller, D. H. Brooks, and D. A. Boas, “Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression,” IEEE Trans. Med. Imaging 28(1), 30–42 (2009).
[Crossref] [PubMed]

Inverse Probl. (1)

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15(2), R41–R93 (1999).
[Crossref]

J. Biomed. Opt. (7)

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Q. Zhang, T. J. Brukilacchio, A. Li, J. J. Stott, T. Chaves, E. Hillman, T. Wu, M. Chorlton, E. Rafferty, R. H. Moore, D. B. Kopans, and D. A. Boas, “Coregistered tomographic x-ray and optical breast imaging: initial results,” J. Biomed. Opt. 10(2), 024033 (2005).
[Crossref] [PubMed]

Y. Lin, D. Thayer, O. Nalcioglu, and G. Gulsen, “Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography,” J. Biomed. Opt. 16(10), 106015 (2011).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

F. S. Azar, K. Lee, A. Khamene, R. Choe, A. Corlu, S. D. Konecky, F. Sauer, and A. G. Yodh, “Standardized platform for coregistration of nonconcurrent diffuse optical and magnetic resonance breast images obtained in different geometries,” J. Biomed. Opt. 12(5), 051902 (2007).
[Crossref] [PubMed]

B. W. Pogue, S. C. Davis, X. Song, B. A. Brooksby, H. Dehghani, and K. D. Paulsen, “Image analysis methods for diffuse optical tomography,” J. Biomed. Opt. 11(3), 033001 (2006).
[Crossref] [PubMed]

F. El-Ghussein, M. A. Mastanduno, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging,” J. Biomed. Opt. 19(1), 011010 (2013).
[Crossref] [PubMed]

Neoplasia (1)

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4(4), 347–354 (2002).
[Crossref] [PubMed]

Opt. Express (2)

Opt. Lett. (4)

Phys. Med. Biol. (2)

P. Hiltunen, S. J. Prince, and S. Arridge, “A combined reconstruction-classification method for diffuse optical tomography,” Phys. Med. Biol. 54(21), 6457–6476 (2009).
[Crossref] [PubMed]

M. Guven, B. Yazici, X. Intes, and B. Chance, “Diffuse optical tomography with a priori anatomical information,” Phys. Med. Biol. 50(12), 2837–2858 (2005).
[Crossref] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (1)

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

Other (1)

B. W. Pogue, S. C. Davis, F. Leblond, M. A. Mastanduno, H. Dehghani, and K. D. Paulsen, “Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value,” Philos. Trans. A Math Phys. Eng. Sci. 369(1955), 4531–4557 (2011).

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Figures (6)

Fig. 1
Fig. 1 (a) The true optical absorption distribution with µa = 0.02mm−1 in target region and µa = 0.01mm−1 in the background, (b) the gray value distribution with 80 in target region and 50 in the background (c) fine mesh for the forward problem, (d) coarse mesh for the inverse problem, with 16 co-located source detector positions placed at regular angles around the object. Red dots indicate the source-detector locations.
Fig. 2
Fig. 2 The reconstructed absorption coefficient images from simulated data are shown, using no prior (left column) and DRI methods with a series of parameters λ=0.01(a), 0.1(b), 1(c), 10(d) and σg=0.001, 0.01, 0.1, 1, 10 (in each column to the right). The unit of x and y axes is mm.
Fig. 3
Fig. 3 (a)-(d) Profiles of the reconstructed absorption coefficient along the X-axis; (e) the reconstructed results of a negative control (no inclusion contrast) with λ = 10 and σg = 0.001, 0.01, 0.1, 1, 10.
Fig. 4
Fig. 4 (a) The full width at half maximum (FWHM) from the cross sectional profiles of the reconstructed inclusions; (b) the bias errors calculated for the reconstructed absorption coefficient images using no prior and DRI methods are shown.
Fig. 5
Fig. 5 MR images from a patient with a malignant lesion (20mm☓27mm☓33mm) seen on DCE MRI. (a): Screenshot of the Nirview 3D surface rendering of the T1 MRI. Fiducial markers and fiber bundle positions are shown; (b): Standard T1 image; and (c): Dynamic contrast-enhanced MRI.
Fig. 6
Fig. 6 The reconstructed HbT images overlaid in three planes with x = −100.0, y = −19.8 and z = −26.6 respectively. (a) Segmented images from corresponding T1 and DCE images. Optical images reconstructed by no priors; (b) and DRI with λ = 1 and σg = 0.001 (c), respectively.

Equations (4)

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S ( x ) = f ( x ) d 2 2 + λ L x 2 2
L i j = { 1 i = j 1 M i exp ( | γ i γ j | 2 2 σ g ) , o t h e r w i s e
Δ x k = ( J k T J k + λ L T L ) 1 J T ( d f ( x k 1 ) )
| B i a s E r r o r | = i N | μ i μ i o | N

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