Matrix effects for pairs of interferents (Al, Na, K, Ba, and Cs) were investigated and compared to predictions of the amount of interference determined by single interferent experiments in order to test a model called the total interference level (TIL), which assumes that the effects of different interferents add linearly. The TIL model is part of an Autonomous Instrument and is designed to indicate when a simple default calibration, such as external calibration or internal standardization, is inadequate for the desired accuracy of analysis. The performance of the TIL model was examined in terms of a daily calibration basis, which should be more accurate, and an occasional calibration basis, which is more convenient, considering simple external standardization and internal standardization as the techniques to be tested for desired accuracy. The results are encouraging for multiple interferences and show that the TIL model can serve a useful function in predicting calibration errors, even given the presence of instrument drift on ICP-MS.

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