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Pump-Probe Imaging of Melanin Identifies Metastatic Potential of Melanoma

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Abstract

Two-color pump-probe microscopy produces chemical contrast between melanins in skin. Increased eumelanin fraction corresponds with worse melanoma prognosis. The spatial heterogeneity of the melanin fraction, both on a cellular and sub-cellular scale, also indicates malignancy.

© 2012 Optical Society of America

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