Diagnosis of early pre-dysplastic stages of colon carcinogenesis using light scattering “fingerprints”

V. Backman; Y. L. Kim; Y. Liu; R. K. Wali; H. K. Roy; M. J. Goldberg; A. K. Kromine; K. Chen

doi:10.1364/FIO.2003.TuR3

Frontiers in Optics
OSA Technical Digest (CD) (Optica Publishing Group, 2003),
paper TuR3
•https://doi.org/10.1364/FIO.2003.TuR3

Diagnosis of early pre-dysplastic stages of colon carcinogenesis using light scattering “fingerprints”

V. Backman, Y. L. Kim, Y. Liu, R. K. Wali, H. K. Roy, M. J. Goldberg, A. K. Kromine, and K. Chen

Frontiers in Optics 2003

Tucson, Arizona United States
5–8 October 2003
ISBN: 1-55752-759-8

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Optical Characterization of Dysplasia (TuR)

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V. Backman, Y. L. Kim, Y. Liu, R. K. Wali, H. K. Roy, M. J. Goldberg, A. K. Kromine, and K. Chen, "Diagnosis of early pre-dysplastic stages of colon carcinogenesis using light scattering “fingerprints”," in Frontiers in Optics, OSA Technical Digest (CD) (Optica Publishing Group, 2003), paper TuR3.

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Abstract

We report detection of slight alterations of tissue micro-architecture by recording multidimensional data characterizing tissue light scattering. In the animal studies, we show that these light scattering “fingerprints” change dramatically even in the earliest pre-dysplastic stages of carcinogenesis, much earlier than currently known histological, molecular, or genetic markers.

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