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Dye-laser-induced thermal Interactions related to cancer treatment using porphyrin photodynamic therapy

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Abstract

Porphyrin photodynamic therapy is an experimental clinical modality currently being used in the treatment of various types of solid tumor.1,2 Photofrin II (a tumor localizing porphyrin) is administered intravenously and then photoactivated in tumor tissue by 630-nm light generated by an argon-pumped dye laser.3 Singlet oxygen is produced by a type II photochemical reaction and is responsible for the initiation of tumoricidai effects of photodynamic therapy (PDT), Recently experiments have been performed which indicate that PDT and hyperthermia can act synergistically.4 In these studies, hyperthermia has been generated by high-frequency microwaves. We have performed experiments designed to document in vivo temperature levels and gradients in tissue during exposure to increasing power densities of red light from a dye laser. In vitro dose rate and nonthermal in vivo dose rate experiments have already been published.5 In addition, we examined the variable of power density of delivered light during PDT as it relates to tumor response.

© 1986 Optical Society of America

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