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Optica Publishing Group
  • Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS)
  • OSA Technical Digest (Optica Publishing Group, 2018),
  • paper BF2C.4
  • https://doi.org/10.1364/BRAIN.2018.BF2C.4

Quantitative tissue spectroscopy techniques for measuring cerebral perfusion and metabolism

Open Access Open Access

Abstract

The brain constitutes 2% of the total body weight but accounts for 20% and 25% of total body basal oxygen and glucose consumption, respectively. As well, the brain has very limited energy storage; thus, it relies on adequate blood flow for oxygen and glucose delivery, and disruption in supply can has devastating effects on the brain. In this talk we’ll present three point-of-care optical sensing techniques that can quantify cerebral perfusion and oxygen metabolism (i.e., cerebral metabolic rate of oxygen and oxygenation state of cytochrome c oxidase). We will describe the technologies (time-resolved spectroscopy, diffuse correlation spectroscopy, and hyperspectral continuous-wave near-infrared spectroscopy), the advanced algorithms we developed to analyze the optical data to convert them into physiological parameters, and some applications in animal models of brain injury and neonatal studies.

© 2018 The Author(s)

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